Professor Marek Lubusky, MD, PhD, MHAProfessor Marek Lubusky, MD, PhD, MHA

Procházka M., Procházka V., Ľubušký M., Procházková J., Hrbáč T. Cerebral venous thrombosis in the users of hormonal contraceptives. Česká neurologie a neurochirurgie, Cesk. Slov. Neurol. N., 2007, 70/103 (5), p. 521-527 (IF-0,037).

ABSTRACT

Cerebral venous thrombosis (CVT) is a dangerous disease with a difficult diagnosis. We present a retrospective analysis of 8 cases of CVT in young women who were hospitalised between April 2004 and October 2005. Thrombophilic markers were examined in all patients. The most common symptoms included headache (100%), vertigo (87.5%), hemiparesis or quadruparesis (62.5%). CT and MRI showed different types of parenchymal lesion infarction or vasogenic inflation in 62.50% and petechial haemorrhage in 25%. DSA venography confirmed the site of occlusion in the lateral and sigmoide sinus in 75%, and superior sagittal sinus (62.5%). We found 3 cases of the homozygous form of methylenetetrahydrofolate reductase (MTHFR-C677T), two patients had a plasminogen activator inhibitor-1 (PAI-1) homozygous mutation. Coexisting thrombophilic risk factors are usually involved in the onset of CVT. Early diagnosis and application of thrombolytic therapy can improve the clinical outcome.



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Professor Marek Lubusky, MD, PhD, MHA

THE FETAL MEDICINE CENTRE
Department of Obstetrics and Gynecology
Palacky University Olomouc, Faculty of Medicine and Dentistry
University Hospital Olomouc
I. P. Pavlova 6, 77520 Olomouc, Czech Republic
Tel: +420 585 852 785
Mobil: +420 606 220 644
E-mail: marek@lubusky.com
Web: www.lubusky.com


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