Professor Marek Lubusky, MD, PhD, MHAProfessor Marek Lubusky, MD, PhD, MHA

Marková I., Ľubušký M., Procházka M., Kudela M., Dušková M., Zapletalová J., Pilka R.Selected immunohistochemical prognostic factors of endometrial cancer

ABSTRACT

Summary: Selected immunohistochemical prognostic factors of endometrial cancer. Objective: To assess the immunohistochemical ex- pression of p53, bcl-2, c-erbB-2, Ki-67, estrogen (ER) and progesterone (PR) receptors, matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-26 (MMP-26) in endometrial cancer patients. To assess the relation between steroid receptor positivity and other markers. Design: Experimental prospective study. Setting: Department of Obstetrics and Gynecology, Department of Genetics, Depart- ment of Pathology, Palacky University Medical School and University Hospital, Olomouc. Methods: We studied 144 cases of primary un- treated endometrial carcinoma in which the p53, bcl-2, c-erbB-2, Ki-67, ER, PR, MMP-7 and MMP-26 antigens were investigated with the use of immunohistochemical methods. We evaluated the correlations between immunohistochemical staining and the age, FIGO stage, grading, depth of invasion and metastatic spread to lymph nodes. Results: Mean age was 65.7 years (range 34–90). p53, bcl-2, c-erbB-2, Ki-67, ER, PR were positive in 35 (24.3 %), 100 (69.4 %), 41 (28.4 %), 65 (45.1 %), 115 (79.8 %) and 127 (88.1 %) cases respectively. MMPs were evaluated in a group of 70 patients, MMP-7 was positive in 33 (47.1 %), MMP-26 in 40 (57.1 %) cases. MMP-7 expression decrea- sed with higher patient age. p53 and Ki-67 overexpression was found to be related to poor differentiation. Immunostaining for bcl-2 co- rrelated with the positivity of steroid receptors status, while immunostaining for c-erbB-2 correlated inversely with ER positive group of cases. Conclusion: The overexpression of p53 and Ki-67 seems to indicate a more malignant phenotype, while bcl-2 expression in de- pendence on steroid receptor positivity could contribute to the identification of high-risk tumors. Key words: endometrial cancer – immunohistochemistry – prognostic factors


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Professor Marek Lubusky, MD, PhD, MHA

THE FETAL MEDICINE CENTRE
Department of Obstetrics and Gynecology
Palacky University Olomouc, Faculty of Medicine and Dentistry
University Hospital Olomouc
I. P. Pavlova 6, 77520 Olomouc, Czech Republic
Tel: +420 585 852 785
Mobil: +420 606 220 644
E-mail: marek@lubusky.com
Web: www.lubusky.com


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